A finding that may lead to a revolutionary drug that truly reverses aging? University of New South Wales (UNSW) analysts have made a discovery that could lead to a revolutionary medication that actually reverses aging, improves DNA repair, and could even help NASA get its astronauts to Mars. In the paper published in Science today, the team identifies a critical step in the molecular process that allows cells to correct damaged DNA. Their experiments in mice suggest a treatment is possible for DNA damage from aging and radiation.
It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission. While our cells have an innate capacity to repair DNA damage-which happens each time we venture out into the sunlight, for example – their ability to get this done declines as we age.
NMN improved their cells’ ability to repair DNA damage triggered by radiation publicity or old age. Professor David Sinclair of UNSW College of Medical Harvard and Sciences Medical College Boston. Human trials of NMN therapy will begin within half a year. Sinclair, who maintains a laboratory at UNSW in Sydney. The work has thrilled NASA, which is taking into consideration the challenge of keeping its astronauts healthy throughout a four-year objective to Mars. On short missions Even, astronauts experience accelerated aging from cosmic radiation, suffering from muscle weakness, memory loss, and other symptoms when they come back.
On a vacation to Mars, the problem would be far worse: five per cent of the astronauts’ cells would die, and their chances of malignancy would approach 100 %. Professor Sinclair and his UNSW colleague Dr. Lindsay Wu were winners in NASA’s iTech competition in December last year. Professor David Sinclair and his UNSW team.
Cosmic radiation isn’t only an issue for astronauts. We are all subjected to it aboard airplanes, with a London-Singapore-Melbourne air travel roughly similar in radiation to a chest x-ray. In theory, the same treatment could mitigate any effects of DNA damage for frequent flyers. The other group that could benefit from this work is survivors of youth cancers. Dr. Wu says 96 per cent of childhood malignancy survivors suffer a chronic disease by age group 45, including coronary disease, Type 2 diabetes, Alzheimer’s disease, and cancers unrelated to the initial cancer.
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For the past four years, Professor Sinclair and Dr. Wu have been focusing on making NMN into a medication substance using their companies MetroBiotech and NSW International. The human trials will start this season at Brigham and Women’s Hospital, in Boston. NMN add momentum to the thrilling work the UNSW Laboratory for Aging Research did within the last four years. They’ve been looking at the interplay of a number of proteins and substances and their roles in the aging process. In 2003, Teacher Sinclair made a connection between the anti-aging enzyme resveratrol and SIRT1, a taking place molecule within tiny amounts in red wine naturally. Source: University of New South Wales — Professor David Sinclair. Remember … Natural is most beneficial!
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